Certified Bioavailable Antioxidants Program

Program Description

Application Process

Compliance

Seal
List of Certified Products

CAP-e Order Form

Sample Certificate

From Formulation to Quality Assurance
Program Description

The Certified Bioavailable Antioxidants Program is a quality assurance program for antioxidant bioavailability. On its own, or as a part of your overall Quality Assurance program, it has been designed to be easily used in your marketing program as well.

The program consists of two parts:
  1. Testing of the product against a placebo, or no product, in humans (Clinical Study)
    1. to examine antioxidant bioavailability at the level of the human body;
    2. to determine a benchmark for lot-to-lot testing.

  2. Testing of the product in the CAP-e assay on a batch-to-batch or lot-to-lot basis at NIS Testing, as determined by your in-house  quality assurance program in conjunction with NIS Testing.
A “Bioavailable Antioxidant” seal on your product packaging, and your advertising for that product, visually tells the consumer a product has proven antioxidant bioavailability.

Clinical Study

This clinical study is designed to generate data that can help you put a bioavailability seal on your product.

It is designed as a stand-alone study but can be part of a larger research strategy. The clinical studies are performed by the Research Division of NIS Labs.

The study evaluates the complete antioxidant capacity of your product, including easily absorbed antioxidants existing in the native product, as well as antioxidant compounds released or generated as a result of normal digestive processes.

The CAP-e bypasses the problem of quantifying “unknown metabolites” which may be part of a product’s total antioxidant capacity. Metabolites don’t need to be chemically identified; as long as they are able to enter and protect living cells from oxidative damage, they contribute to the CAP-e results.

This is in contrast to other types of bioavailability studies, where chemical analysis is performed on serum to examine the sample for metabolites known to have come from the digestion of a natural product.

The clinical study, using the CAP-e test on serum, is different from many other types of bioavailability studies, where specific antioxidants and/or metabolites need to be identifiable in the serum samples. The CAP-e measures the effect of the total antioxidant capacity after consumption of complex products.